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Reciprocal relationship between expression of hypoxia inducible factor 1α (HIF-1α) and the pro-apoptotic protein Bid in ex vivo colorectal cancer
Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1α and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1...
Autores principales: | Seenath, M M, Roberts, D, Cawthorne, C, Saunders, M P, Armstrong, G R, O'Dwyer, S T, Stratford, I J, Dive, C, Renehan, A G |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527799/ https://www.ncbi.nlm.nih.gov/pubmed/18648372 http://dx.doi.org/10.1038/sj.bjc.6604474 |
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