WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

Werner syndrome (WS) is a premature aging disorder caused by mutations in the WS gene (WRN). Although WRN has been suggested to play an important role in DNA metabolic pathways, such as recombination, replication and repair, its precise role still remains to be determined. WRN possesses ATPase, heli...

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Detalles Bibliográficos
Autores principales: Bukowy, Zuzanna, Harrigan, Jeanine A., Ramsden, Dale A., Tudek, Barbara, Bohr, Vilhelm A., Stevnsner, Tinna
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528166/
https://www.ncbi.nlm.nih.gov/pubmed/18658245
http://dx.doi.org/10.1093/nar/gkn468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528166/
https://www.ncbi.nlm.nih.gov/pubmed/18658245
http://dx.doi.org/10.1093/nar/gkn468

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