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WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand
Werner syndrome (WS) is a premature aging disorder caused by mutations in the WS gene (WRN). Although WRN has been suggested to play an important role in DNA metabolic pathways, such as recombination, replication and repair, its precise role still remains to be determined. WRN possesses ATPase, heli...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528166/ https://www.ncbi.nlm.nih.gov/pubmed/18658245 http://dx.doi.org/10.1093/nar/gkn468 |