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Human topoisomerase IIα uses a two-metal-ion mechanism for DNA cleavage
The DNA cleavage reaction of human topoisomerase IIα is critical to all of the physiological and pharmacological functions of the protein. While it has long been known that the type II enzyme requires a divalent metal ion in order to cleave DNA, the role of the cation in this process is not known. T...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528187/ https://www.ncbi.nlm.nih.gov/pubmed/18653531 http://dx.doi.org/10.1093/nar/gkn466 |