Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1

RCC1 is the only known exchange factor for the Ran guanosine triphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear envelope formation. RCC1 binds to chromatin through a bimodal attachment to DNA and histones, and defects in binding cause chromosome misse...

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Detalles Bibliográficos
Autores principales: Hao, Yi, Macara, Ian G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528582/
https://www.ncbi.nlm.nih.gov/pubmed/18762580
http://dx.doi.org/10.1083/jcb.200803110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528582/
https://www.ncbi.nlm.nih.gov/pubmed/18762580
http://dx.doi.org/10.1083/jcb.200803110

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