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Regulation of chromatin binding by a conformational switch in the tail of the Ran exchange factor RCC1
RCC1 is the only known exchange factor for the Ran guanosine triphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear envelope formation. RCC1 binds to chromatin through a bimodal attachment to DNA and histones, and defects in binding cause chromosome misse...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528582/ https://www.ncbi.nlm.nih.gov/pubmed/18762580 http://dx.doi.org/10.1083/jcb.200803110 |