Roles of STAT3/SOCS3 Pathway in Regulating the Visual Function and Ubiquitin-Proteasome-dependent Degradation of Rhodopsin during Retinal Inflammation

Inflammatory cytokines cause tissue dysfunction. We previously reported that retinal inflammation down-regulates rhodopsin expression and impairs visual function by an unknown mechanism. Here, we demonstrate that rhodopsin levels were preserved by suppressor of cytokine signaling 3 (SOCS3), a negati...

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Detalles Bibliográficos
Autores principales: Ozawa, Yoko, Nakao, Keiko, Kurihara, Toshihide, Shimazaki, Takuya, Shimmura, Shigeto, Ishida, Susumu, Yoshimura, Akihiko, Tsubota, Kazuo, Okano, Hideyuki
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Molecular Basis of Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528996/
https://www.ncbi.nlm.nih.gov/pubmed/18614536
http://dx.doi.org/10.1074/jbc.M802238200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528996/
https://www.ncbi.nlm.nih.gov/pubmed/18614536
http://dx.doi.org/10.1074/jbc.M802238200

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