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An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution
BACKGROUND: The origin of nuclear receptors (NRs) and the question whether the ancestral NR was a liganded or an unliganded transcription factor has been recently debated. To obtain insight into the evolution of the ligand binding ability of estrogen receptors (ER), we comparatively characterized th...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529310/ https://www.ncbi.nlm.nih.gov/pubmed/18655705 http://dx.doi.org/10.1186/1471-2148-8-219 |