Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response

Exo1 is a nuclease involved in mismatch repair, DSB repair, stalled replication fork processing and in the DNA damage response triggered by dysfunctional telomeres. In budding yeast and mice, Exo1 creates single-stranded DNA (ssDNA) at uncapped telomeres. This ssDNA accumulation activates the checkp...

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Detalles Bibliográficos
Autores principales: Morin, Isabelle, Ngo, Hien-Ping, Greenall, Amanda, Zubko, Mikhajlo K, Morrice, Nick, Lydall, David
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532783/
https://www.ncbi.nlm.nih.gov/pubmed/18756267
http://dx.doi.org/10.1038/emboj.2008.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532783/
https://www.ncbi.nlm.nih.gov/pubmed/18756267
http://dx.doi.org/10.1038/emboj.2008.171

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