Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice

BACKGROUND: We reported that roflumilast, a phosphodiesterase 4 inhibitor, given orally at 5 mg/kg to mice prevented the development of emphysema in a chronic model of cigarette smoke exposure, while at 1 mg/kg was ineffective. Here we investigated the effects of roflumilast on the volume density (V...

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Detalles Bibliográficos
Autores principales: Martorana, Piero A, Lunghi, Benedetta, Lucattelli, Monica, De Cunto, Giovanna, Beume, Rolf, Lungarella, Giuseppe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533284/
https://www.ncbi.nlm.nih.gov/pubmed/18755021
http://dx.doi.org/10.1186/1471-2466-8-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533284/
https://www.ncbi.nlm.nih.gov/pubmed/18755021
http://dx.doi.org/10.1186/1471-2466-8-17

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