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Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice

BACKGROUND: We reported that roflumilast, a phosphodiesterase 4 inhibitor, given orally at 5 mg/kg to mice prevented the development of emphysema in a chronic model of cigarette smoke exposure, while at 1 mg/kg was ineffective. Here we investigated the effects of roflumilast on the volume density (V...

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Detalles Bibliográficos
Autores principales:	Martorana, Piero A, Lunghi, Benedetta, Lucattelli, Monica, De Cunto, Giovanna, Beume, Rolf, Lungarella, Giuseppe
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533284/ https://www.ncbi.nlm.nih.gov/pubmed/18755021 http://dx.doi.org/10.1186/1471-2466-8-17

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