Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance

BACKGROUND: Thus far gene therapy strategies for HIV/AIDS have used either conventional retroviral vectors or lentiviral vectors for gene transfer. Although highly efficient, their use poses a certain degree of risk in terms of viral mediated oncogenesis. Sleeping Beauty (SB) transposon system offer...

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Detalles Bibliográficos
Autores principales: Tamhane, Mayur, Akkina, Ramesh
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533343/
https://www.ncbi.nlm.nih.gov/pubmed/18667075
http://dx.doi.org/10.1186/1742-6405-5-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533343/
https://www.ncbi.nlm.nih.gov/pubmed/18667075
http://dx.doi.org/10.1186/1742-6405-5-16

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