Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A

The seven antigenically distinct serotypes of Clostridium botulinum neurotoxins, the causative agents of botulism, block the neurotransmitter release by specifically cleaving one of the three SNARE proteins and induce flaccid paralysis. The Centers for Disease Control and Prevention (CDC) has declar...

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Detalles Bibliográficos
Autores principales: Kumaran, Desigan, Rawat, Richa, Ahmed, S. Ashraf, Swaminathan, Subramanyam
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533696/
https://www.ncbi.nlm.nih.gov/pubmed/18818739
http://dx.doi.org/10.1371/journal.ppat.1000165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533696/
https://www.ncbi.nlm.nih.gov/pubmed/18818739
http://dx.doi.org/10.1371/journal.ppat.1000165

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