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Substrate Binding Mode and Its Implication on Drug Design for Botulinum Neurotoxin A
The seven antigenically distinct serotypes of Clostridium botulinum neurotoxins, the causative agents of botulism, block the neurotransmitter release by specifically cleaving one of the three SNARE proteins and induce flaccid paralysis. The Centers for Disease Control and Prevention (CDC) has declar...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533696/ https://www.ncbi.nlm.nih.gov/pubmed/18818739 http://dx.doi.org/10.1371/journal.ppat.1000165 |