Genetic Analysis of the Role of Protein Kinase Cθ in Platelet Function and Thrombus Formation

BACKGROUND: PKCθ is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCθ(−/−) T cells exhibit reduced activation and PKCθ(−/−) mice are resistant to autoimmune disease, making PKCθ an attractive therapeutic target for immune modulation. Collagen is a major agonist...

Descripción completa

Detalles Bibliográficos
Autores principales: Hall, Kellie J., Harper, Matthew T., Gilio, Karen, Cosemans, Judith M., Heemskerk, Johan W. M., Poole, Alastair W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533697/
https://www.ncbi.nlm.nih.gov/pubmed/18815612
http://dx.doi.org/10.1371/journal.pone.0003277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533697/
https://www.ncbi.nlm.nih.gov/pubmed/18815612
http://dx.doi.org/10.1371/journal.pone.0003277

Ejemplares similares