Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

BACKGROUND: Regulated intramembrane proteolysis of the β-amyloid precursor protein by the γ-secretase yields two peptides. One, amyloid-β, is the major component of the amyloid plaques found in Alzheimer's disease patients. The other, APP IntraCellular Domain, has been involved in regulation of...

Descripción completa

Detalles Bibliográficos
Autores principales: Giliberto, Luca, Zhou, Dawang, Weldon, Richard, Tamagno, Elena, De Luca, Pasquale, Tabaton, Massimo, D'Adamio, Luciano
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538519/
https://www.ncbi.nlm.nih.gov/pubmed/18764939
http://dx.doi.org/10.1186/1750-1326-3-12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538519/
https://www.ncbi.nlm.nih.gov/pubmed/18764939
http://dx.doi.org/10.1186/1750-1326-3-12

Ejemplares similares