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Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

BACKGROUND: Regulated intramembrane proteolysis of the β-amyloid precursor protein by the γ-secretase yields two peptides. One, amyloid-β, is the major component of the amyloid plaques found in Alzheimer's disease patients. The other, APP IntraCellular Domain, has been involved in regulation of...

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Detalles Bibliográficos
Autores principales:	Giliberto, Luca, Zhou, Dawang, Weldon, Richard, Tamagno, Elena, De Luca, Pasquale, Tabaton, Massimo, D'Adamio, Luciano
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538519/ https://www.ncbi.nlm.nih.gov/pubmed/18764939 http://dx.doi.org/10.1186/1750-1326-3-12

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