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Protein Docking by the Underestimation of Free Energy Funnels in the Space of Encounter Complexes

Similarly to protein folding, the association of two proteins is driven by a free energy funnel, determined by favorable interactions in some neighborhood of the native state. We describe a docking method based on stochastic global minimization of funnel-shaped energy functions in the space of rigid...

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Detalles Bibliográficos
Autores principales: Shen, Yang, Paschalidis, Ioannis Ch., Vakili, Pirooz, Vajda, Sandor
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538569/
https://www.ncbi.nlm.nih.gov/pubmed/18846200
http://dx.doi.org/10.1371/journal.pcbi.1000191