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Protein Docking by the Underestimation of Free Energy Funnels in the Space of Encounter Complexes
Similarly to protein folding, the association of two proteins is driven by a free energy funnel, determined by favorable interactions in some neighborhood of the native state. We describe a docking method based on stochastic global minimization of funnel-shaped energy functions in the space of rigid...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538569/ https://www.ncbi.nlm.nih.gov/pubmed/18846200 http://dx.doi.org/10.1371/journal.pcbi.1000191 |