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Constraints imposed by non-functional protein–protein interactions on gene expression and proteome size

Crowded intracellular environments present a challenge for proteins to form functional specific complexes while reducing non-functional interactions with promiscuous non-functional partners. Here we show how the need to minimize the waste of resources to non-functional interactions limits the proteo...

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Detalles Bibliográficos
Autores principales: Zhang, Jingshan, Maslov, Sergei, Shakhnovich, Eugene I
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538908/
https://www.ncbi.nlm.nih.gov/pubmed/18682700
http://dx.doi.org/10.1038/msb.2008.48