The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL–C3G-mediated activation of Rap1

WAVE2 regulates T cell receptor (TCR)–stimulated actin cytoskeletal dynamics leading to both integrin clustering and affinity maturation. Although WAVE2 mediates integrin affinity maturation by recruiting vinculin and talin to the immunological synapse in an Arp2/3-dependent manner, the mechanism by...

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Detalles Bibliográficos
Autores principales: Nolz, Jeffrey C., Nacusi, Lucas P., Segovis, Colin M., Medeiros, Ricardo B., Mitchell, Jason S., Shimizu, Yoji, Billadeau, Daniel D.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542481/
https://www.ncbi.nlm.nih.gov/pubmed/18809728
http://dx.doi.org/10.1083/jcb.200801121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542481/
https://www.ncbi.nlm.nih.gov/pubmed/18809728
http://dx.doi.org/10.1083/jcb.200801121

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