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Speeding through cell cycle roadblocks: Nuclear cyclin D1-dependent kinase and neoplastic transformation
Mitogenic induction of cyclin D1, the allosteric regulator of CDK4/6, is a key regulatory event contributing to G1 phase progression. Following the G1/S transition, cyclin D1 activation is antagonized by GSK3β-dependent threonine-286 (Thr-286) phosphorylation, triggering nuclear export and subsequen...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543001/ https://www.ncbi.nlm.nih.gov/pubmed/18764945 http://dx.doi.org/10.1186/1747-1028-3-12 |