A Myo6 Mutation Destroys Coordination between the Myosin Heads, Revealing New Functions of Myosin VI in the Stereocilia of Mammalian Inner Ear Hair Cells

Myosin VI, found in organisms from Caenorhabditis elegans to humans, is essential for auditory and vestibular function in mammals, since genetic mutations lead to hearing impairment and vestibular dysfunction in both humans and mice. Here, we show that a missense mutation in this molecular motor in...

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Detalles Bibliográficos
Autores principales: Hertzano, Ronna, Shalit, Ella, Rzadzinska, Agnieszka K., Dror, Amiel A., Song, Lin, Ron, Uri, Tan, Joshua T., Shitrit, Alina Starovolsky, Fuchs, Helmut, Hasson, Tama, Ben-Tal, Nir, Sweeney, H. Lee, de Angelis, Martin Hrabe, Steel, Karen P., Avraham, Karen B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543112/
https://www.ncbi.nlm.nih.gov/pubmed/18833301
http://dx.doi.org/10.1371/journal.pgen.1000207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543112/
https://www.ncbi.nlm.nih.gov/pubmed/18833301
http://dx.doi.org/10.1371/journal.pgen.1000207

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