Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT

All chaperonins mediate ATP-dependent polypeptide folding by confining substrates within a central chamber. Intriguingly, the eukaryotic chaperonin TRiC (also called CCT) uses a built-in lid to close the chamber, whereas prokaryotic chaperonins use a detachable lid. Here we determine the mechanism o...

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Detalles Bibliográficos
Autores principales: Booth, Christopher R, Meyer, Anne S, Cong, Yao, Topf, Maya, Sali, Andrej, Ludtke, Steven J, Chiu, Wah, Frydman, Judith
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546500/
https://www.ncbi.nlm.nih.gov/pubmed/18536725
http://dx.doi.org/10.1038/nsmb.1436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546500/
https://www.ncbi.nlm.nih.gov/pubmed/18536725
http://dx.doi.org/10.1038/nsmb.1436

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