CD28/CD154 Blockade Prevents Autoimmune Diabetes by Inducing Nondeletional Tolerance After Effector T-Cell Inhibition and Regulatory T-Cell Expansion

OBJECTIVE—Blocking T-cell signaling is an effective means to prevent autoimmunity and allograft rejection in many animal models, yet the clinical translation of many of these approaches has not resulted in the success witnessed in experimental systems. Improved understanding of these approaches may...

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Detalles Bibliográficos
Autores principales: Rigby, Mark R., Trexler, Alison M., Pearson, Thomas C., Larsen, Christian P.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551677/
https://www.ncbi.nlm.nih.gov/pubmed/18492787
http://dx.doi.org/10.2337/db07-1712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551677/
https://www.ncbi.nlm.nih.gov/pubmed/18492787
http://dx.doi.org/10.2337/db07-1712

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