Transforming Growth Factor-β Suppresses the Activation of CD8(+) T-Cells When Naïve but Promotes Their Survival and Function Once Antigen Experienced : A Two-Faced Impact on Autoimmunity

OBJECTIVE—Transforming growth factor-β (TGF-β) can exhibit strong immune suppression but has also been shown to promote T-cell growth. We investigated the differential effect of this cytokine on CD8(+) T-cells in autoimmunity and antiviral immunity. RESEARCH DESIGN AND METHODS—We used mouse models f...

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Detalles Bibliográficos
Autores principales: Filippi, Christophe M., Juedes, Amy E., Oldham, Janine E., Ling, Ellie, Togher, Lisa, Peng, Yufeng, Flavell, Richard A., von Herrath, Matthias G.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551678/
https://www.ncbi.nlm.nih.gov/pubmed/18689691
http://dx.doi.org/10.2337/db08-0609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551678/
https://www.ncbi.nlm.nih.gov/pubmed/18689691
http://dx.doi.org/10.2337/db08-0609

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