Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

OBJECTIVE—Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic β-cells, resulting in reduced insulin content, defective insulin secretion, and apoptosis. We investigated the involvement in t...

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Detalles Bibliográficos
Autores principales: Lovis, Pascal, Roggli, Elodie, Laybutt, D. Ross, Gattesco, Sonia, Yang, Jiang-Yan, Widmann, Christian, Abderrahmani, Amar, Regazzi, Romano
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551683/
https://www.ncbi.nlm.nih.gov/pubmed/18633110
http://dx.doi.org/10.2337/db07-1252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551683/
https://www.ncbi.nlm.nih.gov/pubmed/18633110
http://dx.doi.org/10.2337/db07-1252

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