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Explaining oscillations and variability in the p53-Mdm2 system
BACKGROUND: In individual living cells p53 has been found to be expressed in a series of discrete pulses after DNA damage. Its negative regulator Mdm2 also demonstrates oscillatory behaviour. Attempts have been made recently to explain this behaviour by mathematical models but these have not address...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2008
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553322/ https://www.ncbi.nlm.nih.gov/pubmed/18706112 http://dx.doi.org/10.1186/1752-0509-2-75 |