Gating Pore Currents in DIIS4 Mutations of NaV1.4 Associated with Periodic Paralysis: Saturation of Ion Flux and Implications for Disease Pathogenesis

S4 voltage–sensor mutations in CaV1.1 and NaV1.4 channels cause the human muscle disorder hypokalemic periodic paralysis (HypoPP). The mechanism whereby these mutations predispose affected sarcolemma to attacks of sustained depolarization and loss of excitability is poorly understood. Recently, thre...

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Detalles Bibliográficos
Autores principales: Struyk, Arie F., Markin, Vladislav S., Francis, David, Cannon, Stephen C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553391/
https://www.ncbi.nlm.nih.gov/pubmed/18824591
http://dx.doi.org/10.1085/jgp.200809967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553391/
https://www.ncbi.nlm.nih.gov/pubmed/18824591
http://dx.doi.org/10.1085/jgp.200809967

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