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Clinical consequences of asbestos-related diffuse pleural thickening: A review

Asbestos-related diffuse pleural thickening (DPT), or extensive fibrosis of the visceral pleura secondary to asbestos exposure, is increasingly common due to the large number of workers previously exposed to asbestos. It may coexist with asbestos related pleural plaques but has a distinctly differen...

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Detalles Bibliográficos
Autores principales: Miles, Susan E, Sandrini, Alessandra, Johnson, Anthony R, Yates, Deborah H
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553409/
https://www.ncbi.nlm.nih.gov/pubmed/18775081
http://dx.doi.org/10.1186/1745-6673-3-20
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author Miles, Susan E
Sandrini, Alessandra
Johnson, Anthony R
Yates, Deborah H
author_facet Miles, Susan E
Sandrini, Alessandra
Johnson, Anthony R
Yates, Deborah H
author_sort Miles, Susan E
collection PubMed
description Asbestos-related diffuse pleural thickening (DPT), or extensive fibrosis of the visceral pleura secondary to asbestos exposure, is increasingly common due to the large number of workers previously exposed to asbestos. It may coexist with asbestos related pleural plaques but has a distinctly different pathology. The pathogenesis of this condition as distinct from pleural plaques is gradually becoming understood. Generation of reactive oxygen and nitrogen species, profibrotic cytokines and growth factors in response to asbestos is likely to play a role in the formation of a fibrinous intrapleural matrix. Benign asbestos related pleural effusions commonly antedate the development of diffuse pleural thickening. Environmental as well as occupational exposure to asbestos may also result in pleural fibrosis, particularly in geographic areas with naturally occurring asbestiform soil minerals. Pleural disorders may also occur after household exposure. High resolution computed tomography (CT) is more sensitive and specific than chest radiography for the diagnosis of diffuse pleural thickening, and several classification systems for asbestos-related disorders have been devised. Magnetic resonance imaging and fluorodeoxyglucose positron emission tomography (PET) scanning may be useful in distinguishing between DPT and malignant mesothelioma. DPT may be associated with symptoms such as dyspnoea and chest pain. It causes a restrictive defect on lung function and may rarely result in respiratory failure and death. Treatment is primarily supportive.
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spelling pubmed-25534092008-09-26 Clinical consequences of asbestos-related diffuse pleural thickening: A review Miles, Susan E Sandrini, Alessandra Johnson, Anthony R Yates, Deborah H J Occup Med Toxicol Review Asbestos-related diffuse pleural thickening (DPT), or extensive fibrosis of the visceral pleura secondary to asbestos exposure, is increasingly common due to the large number of workers previously exposed to asbestos. It may coexist with asbestos related pleural plaques but has a distinctly different pathology. The pathogenesis of this condition as distinct from pleural plaques is gradually becoming understood. Generation of reactive oxygen and nitrogen species, profibrotic cytokines and growth factors in response to asbestos is likely to play a role in the formation of a fibrinous intrapleural matrix. Benign asbestos related pleural effusions commonly antedate the development of diffuse pleural thickening. Environmental as well as occupational exposure to asbestos may also result in pleural fibrosis, particularly in geographic areas with naturally occurring asbestiform soil minerals. Pleural disorders may also occur after household exposure. High resolution computed tomography (CT) is more sensitive and specific than chest radiography for the diagnosis of diffuse pleural thickening, and several classification systems for asbestos-related disorders have been devised. Magnetic resonance imaging and fluorodeoxyglucose positron emission tomography (PET) scanning may be useful in distinguishing between DPT and malignant mesothelioma. DPT may be associated with symptoms such as dyspnoea and chest pain. It causes a restrictive defect on lung function and may rarely result in respiratory failure and death. Treatment is primarily supportive. BioMed Central 2008-09-08 /pmc/articles/PMC2553409/ /pubmed/18775081 http://dx.doi.org/10.1186/1745-6673-3-20 Text en Copyright © 2008 Miles et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Miles, Susan E
Sandrini, Alessandra
Johnson, Anthony R
Yates, Deborah H
Clinical consequences of asbestos-related diffuse pleural thickening: A review
title Clinical consequences of asbestos-related diffuse pleural thickening: A review
title_full Clinical consequences of asbestos-related diffuse pleural thickening: A review
title_fullStr Clinical consequences of asbestos-related diffuse pleural thickening: A review
title_full_unstemmed Clinical consequences of asbestos-related diffuse pleural thickening: A review
title_short Clinical consequences of asbestos-related diffuse pleural thickening: A review
title_sort clinical consequences of asbestos-related diffuse pleural thickening: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553409/
https://www.ncbi.nlm.nih.gov/pubmed/18775081
http://dx.doi.org/10.1186/1745-6673-3-20
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