RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model

We investigated the roles played by the cysteine proteases cathepsin B and cathepsin L (brucipain) in the pathogenesis of Trypansoma brucei brucei in both an in vivo mouse model and an in vitro model of the blood–brain barrier. Doxycycline induction of RNAi targeting cathepsin B led to parasite clea...

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Detalles Bibliográficos
Autores principales: Abdulla, Maha-Hamadien, O'Brien, Theresa, Mackey, Zachary B., Sajid, Mohamed, Grab, Dennis J., McKerrow, James H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553486/
https://www.ncbi.nlm.nih.gov/pubmed/18820745
http://dx.doi.org/10.1371/journal.pntd.0000298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553486/
https://www.ncbi.nlm.nih.gov/pubmed/18820745
http://dx.doi.org/10.1371/journal.pntd.0000298

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