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RNA Interference of Trypanosoma brucei Cathepsin B and L Affects Disease Progression in a Mouse Model
We investigated the roles played by the cysteine proteases cathepsin B and cathepsin L (brucipain) in the pathogenesis of Trypansoma brucei brucei in both an in vivo mouse model and an in vitro model of the blood–brain barrier. Doxycycline induction of RNAi targeting cathepsin B led to parasite clea...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553486/ https://www.ncbi.nlm.nih.gov/pubmed/18820745 http://dx.doi.org/10.1371/journal.pntd.0000298 |