Homogeneity and persistence of transgene expression by omitting antibiotic selection in cell line isolation

Nonuniform, mosaic expression patterns of transgenes are often linked to transcriptional silencing, triggered by epigenetic modifications of the exogenous DNA. Such phenotypes are common phenomena in genetically engineered cells and organisms. They are widely attributed to features of transgenic tra...

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Detalles Bibliográficos
Autores principales: Kaufman, Weimin L., Kocman, Ibrahim, Agrawal, Vishal, Rahn, Hans-Peter, Besser, Daniel, Gossen, Manfred
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553579/
https://www.ncbi.nlm.nih.gov/pubmed/18682524
http://dx.doi.org/10.1093/nar/gkn508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553579/
https://www.ncbi.nlm.nih.gov/pubmed/18682524
http://dx.doi.org/10.1093/nar/gkn508

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