A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance

Human DNA topoisomerase I (hTop1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of the antitumor drug camptothecin (CPT). The X-ray crystal structure of the enzyme covalently joined to DNA and bound to the CPT analog Topotecan suggests that there are two classes of...

Descripción completa

Detalles Bibliográficos
Autores principales: Losasso, Carmen, Cretaio, Erica, Fiorani, Paola, D’Annessa, Ilda, Chillemi, Giovanni, Benedetti, Piero
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553582/
https://www.ncbi.nlm.nih.gov/pubmed/18772225
http://dx.doi.org/10.1093/nar/gkn557

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553582/
https://www.ncbi.nlm.nih.gov/pubmed/18772225
http://dx.doi.org/10.1093/nar/gkn557

Ejemplares similares