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A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance

Human DNA topoisomerase I (hTop1p) catalyzes the relaxation of supercoiled DNA and constitutes the cellular target of the antitumor drug camptothecin (CPT). The X-ray crystal structure of the enzyme covalently joined to DNA and bound to the CPT analog Topotecan suggests that there are two classes of...

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Detalles Bibliográficos
Autores principales:	Losasso, Carmen, Cretaio, Erica, Fiorani, Paola, D’Annessa, Ilda, Chillemi, Giovanni, Benedetti, Piero
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553582/ https://www.ncbi.nlm.nih.gov/pubmed/18772225 http://dx.doi.org/10.1093/nar/gkn557

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