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Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage
Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood. We establish by genetic means that CL targets DNA gyrase in the Gram-positive bacterium Streptococcus pneu...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553588/ https://www.ncbi.nlm.nih.gov/pubmed/18723572 http://dx.doi.org/10.1093/nar/gkn539 |