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Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage

Clerocidin (CL), a microbial diterpenoid, reacts with DNA via its epoxide group and stimulates DNA cleavage by type II DNA topoisomerases. The molecular basis of CL action is poorly understood. We establish by genetic means that CL targets DNA gyrase in the Gram-positive bacterium Streptococcus pneu...

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Detalles Bibliográficos
Autores principales:	Pan, Xiao Su, Dias, Miriam, Palumbo, Manlio, Fisher, L. Mark
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553588/ https://www.ncbi.nlm.nih.gov/pubmed/18723572 http://dx.doi.org/10.1093/nar/gkn539

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