DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts

Replication origins in Xenopus egg extracts are located at apparently random sequences but are activated in clusters that fire at different times during S phase under the control of ATR/ATM kinases. We investigated whether chromosomal domains and single sequences replicate at distinct times during S...

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Detalles Bibliográficos
Autores principales: Labit, Hélène, Perewoska, Irène, Germe, Thomas, Hyrien, Olivier, Marheineke, Kathrin
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553594/
https://www.ncbi.nlm.nih.gov/pubmed/18765475
http://dx.doi.org/10.1093/nar/gkn533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553594/
https://www.ncbi.nlm.nih.gov/pubmed/18765475
http://dx.doi.org/10.1093/nar/gkn533

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