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Interconvertible Lac Repressor–DNA Loops Revealed by Single-Molecule Experiments

At many promoters, transcription is regulated by simultaneous binding of a protein to multiple sites on DNA, but the structures and dynamics of such transcription factor-mediated DNA loops are poorly understood. We directly examined in vitro loop formation mediated by Escherichia coli lactose repres...

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Detalles Bibliográficos
Autores principales: Wong, Oi Kwan, Guthold, Martin, Erie, Dorothy A, Gelles, Jeff
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553838/
https://www.ncbi.nlm.nih.gov/pubmed/18828671
http://dx.doi.org/10.1371/journal.pbio.0060232