Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis

We have obtained precatalytic (enzyme–substrate complex) and postcatalytic (enzyme–product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modul...

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Detalles Bibliográficos
Autores principales: Chi, Young-In, Martick, Monika, Lares, Monica, Kim, Rosalind, Scott, William G, Kim, Sung-Hou
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553840/
https://www.ncbi.nlm.nih.gov/pubmed/18834200
http://dx.doi.org/10.1371/journal.pbio.0060234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553840/
https://www.ncbi.nlm.nih.gov/pubmed/18834200
http://dx.doi.org/10.1371/journal.pbio.0060234

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