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Capturing Hammerhead Ribozyme Structures in Action by Modulating General Base Catalysis
We have obtained precatalytic (enzyme–substrate complex) and postcatalytic (enzyme–product complex) crystal structures of an active full-length hammerhead RNA that cleaves in the crystal. Using the natural satellite tobacco ringspot virus hammerhead RNA sequence, the self-cleavage reaction was modul...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553840/ https://www.ncbi.nlm.nih.gov/pubmed/18834200 http://dx.doi.org/10.1371/journal.pbio.0060234 |