Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development

BACKGROUND: Type I diabetes (TID) is an autoimmune disease resulting from destruction of the insulin-producing β-cells by autoreactive T cells. Studies have shown that polymorphisms of chemokine CXCL12 gene are linked to TID in humans. In non-obese diabetic (NOD) mice, which are predisposed to devel...

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Detalles Bibliográficos
Autores principales: Leng, Qibin, Nie, Yuchun, Zou, Yongrui, Chen, Jianzhu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556327/
https://www.ncbi.nlm.nih.gov/pubmed/18793419
http://dx.doi.org/10.1186/1471-2172-9-51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556327/
https://www.ncbi.nlm.nih.gov/pubmed/18793419
http://dx.doi.org/10.1186/1471-2172-9-51

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