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Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts

B cells activated by antigen in T cell–dependent immune responses can become short-lived plasma cells, which remain in the spleen, or germinal center–derived memory or plasma cells, which show evidence of affinity maturation and, in the case of plasma cells, migrate to the bone marrow. We show that...

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Detalles Bibliográficos
Autores principales: Kim, Sun Jung, Caton, Michele, Wang, Chuansheng, Khalil, Magi, Zhou, Zhi-Jie, Hardin, John, Diamond, Betty
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556778/
https://www.ncbi.nlm.nih.gov/pubmed/18809711
http://dx.doi.org/10.1084/jem.20070731