Tissue specific promoters improve specificity of AAV9 mediated transgene expression following intra-vascular gene delivery in neonatal mice

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The AAV9 capsid displays a high natural affinity for the heart following a single intravenous (IV) administration in both newborn and adult mice. It also results in substantial albeit relatively lower expression levels in many other tissues. To increase the overall safety of this gene delivery metho...

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Detalles Bibliográficos
Autores principales: Pacak, Christina A, Sakai, Yoshihisa, Thattaliyath, Bijoy D, Mah, Cathryn S, Byrne, Barry J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Short Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557000/
https://www.ncbi.nlm.nih.gov/pubmed/18811960
http://dx.doi.org/10.1186/1479-0556-6-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557000/
https://www.ncbi.nlm.nih.gov/pubmed/18811960
http://dx.doi.org/10.1186/1479-0556-6-13

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