Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

Although Akt is known as a survival kinase, inhibitors of the phosphatidylinositol 3-kinase (PI3K)–Akt pathway do not always induce substantial apoptosis. We show that silencing Akt1 alone, or any combination of Akt isoforms, can suppress the growth of tumors established from phosphatase and tensin...

Descripción completa

Detalles Bibliográficos
Autores principales: Degtyarev, Michael, De Mazière, Ann, Orr, Christine, Lin, Jie, Lee, Brian B., Tien, Janet Y., Prior, Wei W., van Dijk, Suzanne, Wu, Hong, Gray, Daniel C., Davis, David P., Stern, Howard M., Murray, Lesley J., Hoeflich, Klaus P., Klumperman, Judith, Friedman, Lori S., Lin, Kui
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557046/
https://www.ncbi.nlm.nih.gov/pubmed/18838554
http://dx.doi.org/10.1083/jcb.200801099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557046/
https://www.ncbi.nlm.nih.gov/pubmed/18838554
http://dx.doi.org/10.1083/jcb.200801099

Ejemplares similares