Genome Wide Identification of Recessive Cancer Genes by Combinatorial Mutation Analysis

We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene deletions. We studied over 20,000 genes in 3 Gigabas...

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Detalles Bibliográficos
Autores principales: Volinia, Stefano, Mascellani, Nicoletta, Marchesini, Jlenia, Veronese, Angelo, Ormondroyd, Elizabeth, Alder, Hansjuerg, Palatini, Jeff, Negrini, Massimo, Croce, Carlo M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557123/
https://www.ncbi.nlm.nih.gov/pubmed/18846217
http://dx.doi.org/10.1371/journal.pone.0003380

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557123/
https://www.ncbi.nlm.nih.gov/pubmed/18846217
http://dx.doi.org/10.1371/journal.pone.0003380

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