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Genome Wide Identification of Recessive Cancer Genes by Combinatorial Mutation Analysis
We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene deletions. We studied over 20,000 genes in 3 Gigabas...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2557123/ https://www.ncbi.nlm.nih.gov/pubmed/18846217 http://dx.doi.org/10.1371/journal.pone.0003380 |