Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential

PURPOSE: Safety and efficiency are critical for successful gene therapy. Adeno-associated viral (AAV) vectors are commonly used for gene transfer in both human and animal studies. However, administration of AAV vectors can lead to development of neutralizing antibodies against the vector capsid, thu...

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Detalles Bibliográficos
Autores principales: Li, Qiuhong, Miller, Rehae, Han, Ping-Yang, Pang, Jijing, Dinculescu, Astra, Chiodo, Vince, Hauswirth, William W.
Formato: Texto
Lenguaje:English
Publicado: Molecular Vision 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559816/
https://www.ncbi.nlm.nih.gov/pubmed/18836574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2559816/
https://www.ncbi.nlm.nih.gov/pubmed/18836574

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