ROCK1 and LIMK2 Interact in Spread but Not Blebbing Cancer Cells

Cancer cells migrating within a 3D microenvironment are able to adopt either a mesenchymal or amoeboid mode of migration. Amoeboid migration is characterised by membrane blebbing that is dependent on the Rho effectors, ROCK1/2. We identify LIMK2 as the preferred substrate for ROCK1 but find that LIM...

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Detalles Bibliográficos
Autores principales: Shea, Kerry F., Wells, Claire M., Garner, Andrew P., Jones, Gareth E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561063/
https://www.ncbi.nlm.nih.gov/pubmed/18852895
http://dx.doi.org/10.1371/journal.pone.0003398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561063/
https://www.ncbi.nlm.nih.gov/pubmed/18852895
http://dx.doi.org/10.1371/journal.pone.0003398

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