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Triple-helix structure in telomerase RNA contributes to catalysis

Telomerase is responsible for replication of the ends of linear chromosomes in most eukaryotes. Its intrinsic RNA subunit provides the template for synthesis of telomeric DNA by the reverse-transcriptase (TERT) subunit and tethers other proteins into the ribonucleoprotein (RNP) complex. We report th...

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Detalles Bibliográficos
Autores principales: Qiao, Feng, Cech, Thomas R
Formato: Texto
Lenguaje:English
Publicado: 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562722/
https://www.ncbi.nlm.nih.gov/pubmed/18500353
http://dx.doi.org/10.1038/nsmb.1420